The motion of intra- and extra-vascular biological fluids with particular reference to the rheological characteristics and the motion of fluids particulates. Diffusive and convective mass transport through porous or continuous steady-state or time-varying membranes. Active and passive transport across biological and synthetic membranes, both thin and thick. Mass exchange between blood and extravascular fluids. Flows, osmotic and electrochemical equilibrium. Facilitated diffusion through membranes via specific carrier or due to specific flow conditions. Acid-base balance. Models of organ function (brain, kidney, lung, placenta, liver). Equipment for the controlled release of drugs. Distribution models of intra- and extra-vascular fluids. Difference between support systems of vital functions intra-, extra-, para-corporeal and directions to the choice depending on the type of use and life system. Classification based on the duration of the support application. Design criteria and evaluation of supports for the cardiovascular system: counterpulsers, axial blood pumps, rotary blood pumps, assistance ventricles, artificial heart. Criteria for the design and evaluation of mechanical and circulatory support for the respiratory system: gas ventilators, iron lung, systems for liquid ventilation, partial and total extracorporeal oxygenation. Design criteria and evaluation of media for renal function: hemodialysis, hemodiafiltration, peritoneal dialysis. Criteria for the design and evaluation of media for the liver function. Supports for the pancreatic function: pumps and systems for the release of insulin, artificial pancreas. Evaluation and optimization of the machine-patient interface.
Biomedical engineering notes